�UroToday.com - Dr. Arto Salonen and Finnish colleagues compared intermittent androgen deprivation (IAD) to continuous androgenic hormone deprivation (CAD) in 856 patients with locally ripe or metastatic prostate cancer (CaP) toughened at 27 clinics in Finland. This report represents an interim analysis of their information.
The patients were accrued between 1997 and 2003 and had a life expectancy of at least 12 months. A 24 week run in of continuous LHRH agonist therapy preceded randomisation for those who had a PSA decrease to
Mean patient age was 72 eld and mean PSA at entry was 383ng/ml. Patients had stage T3 tumors (61%) and stage T4 tumors (29%). A total of 564 men completed the quarrel period and 279 were randomized to IAD and 285 to CAD. PSA, alkaline phosphatase, proportion of T4 tumors, poorly differentiated tumors, metastatic disease, and skeletal hot spots among patients with M1 disease were significantly higher in the IAD group. Baseline testosterone was not significant in the analysis.
A significant proportion of patients with the most fast-growing and advanced CaP did not respond to androgen deprivation therapy. The investigators concluded that IAD appears feasible for patients with locally advanced, hormone sensitive CaP. A low bound of testosterone at baseline did non select for IAD or CAD. Patients with advanced CaP, with a high PSA, alkaline phosphatase and metastatic disease, with more than than 5 skeletal hot spots, did not show up adequate biochemical response to ADT. Thus, they ar not good candidates for IAD and other modalities should be considered.
Salonen AJ, Viitanen J, Lundstedt S, Ala-Opas M, Taari K, Tammela TL
J Urol. 2008 Jul 15. Epub ahead of print.
doi:10.1016/j.juro.2008.05.009
Reported by UroToday.com Contributing Editor Christopher P. Evans, MD, FACS
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Tuesday, 19 August 2008
Saturday, 9 August 2008
Tuesday, 1 July 2008
Glastonbury festival: final day, Pilton, Somerset
The rain held off, and so did the vultures. After all the negative publicity, the sense of relief no doubt felt by the organisers on Sunday was mirrored in the mellow cheerfulness of the crowds. Sundays at Glastonbury have a hazy, meandering feel, anyway. This year, you could take in Ladyhawke's 1980s pop in the Queen's Head, or go to Dance East for some Day-Glo face paint and Rex the Dog electro-house. If the sunshine had made you exceptionally generous, you could even watch trustafarian troubadour Newton Faulkner cover Dead or Alive's You Spin Me Round (Like a Record).
Later, Billy Bragg joined Carl Barât for some Libertines songs, and Manu Chao was the Reduced Shakespeare Company of world music: all the most popular bits performed very, very fast. Meanwhile, Mark Ronson demonstrated his ability to make any song sound like Saturday night ITV and hosted the most uncomfortable guest appearance of the weekend: a Lily Allen so devastated by a bereavement the day before (her grandmother) that she cried and forgot the lyrics.
When Goldfrapp played here five years ago, Alison Goldfrapp's look was S&M Weimar disco. This time, it was hippy folk priestess: there was even a maypole on stage. A run of delicate new material made a suitably bucolic soundtrack to the dipping sun, but it was the glitterball pulse of Ooh La La that ignited the set. One minute the dancers were wearing white robes and flowers, the next they were in black bikinis and wolf masks.
In the past, the Sunday afternoon Pyramid stage slot has hosted the likes of Al Green, Brian Wilson and Shirley Bassey. Neil Diamond - whose face shows how good you can look at 67 if you are the only man in pop who didn't do drugs in the 1960s - lies towards the Bassey end of the spectrum. He may have had a critical resurgence with two autumnal Rick Rubin-produced albums, but he remains resolutely uncool. Beautiful Noise was pure corn, and Medicine Man could be no more redolent of 1973 if he performed it wearing a Nixon mask. It took Sweet Caroline to prompt the mass singalong this slot demands.
Leonard Cohen also required, and received, the crowd's patience. Clearly, few people knew his later material, but curiosity kept them hanging around for an extraordinary troika of Tower of Song, Suzanne and Hallelujah. The latter song has been performed here before, but never by the man who wrote it, never with such wracked intensity, and never to such a glorious response.
The boos that greeted Richard Ashcroft's shout-out to Jay-Z suggested the Verve were who the Gallagherites had been waiting for. This is Glastonbury's comfort zone: big, mate-hugging indie anthems. They do it with aplomb; during Bitter Sweet Symphony, Ashcroft even raised his sunglasses, for once, to survey the sea of arms. But what saved Glastonbury this year was the willingness of festival-goers to give something different a chance.
See Also
Tuesday, 24 June 2008
Hardline
Artist: Hardline
Genre(s):
Other
Rock
Discography:
Stik 099
Year: 2004
Tracks: 1
Double Eclipse
Year: 1992
Tracks: 13
Guitar machine gunner Neal Schon played as a adolescent with Santana. Then, he founded Journey and rode their radio wave piece soundless reaching proscribed to Jan Hammer and Sammy Hagar for creative freedom and chop flexing. In the late '80s, he joined Bad English, which was bad theme since isaac Bashevis Singer John Waite and fellow Journey keyboardist Jonathan Cain (both ex-Babys) captive Schon's hammer-down tendencies precisely like Journey. He ultimately got what he wanted with the tomentum unit Hardline: Bad English drummer Deen Castronovo drafted womb-to-tomb buddy Todd Jensen (sometime David Lee Roth) for bass part duty. Frontman Johnny Gioeli and his guitar player brother, Joey, already wrote songs together in Brunette. Hardline's debut, Double Eclipse, saw some MTV and radio action with "Takin' Me Down." Schon let proscribed some of the stored-up slashing he had tenacious suppressed. However, the early-'90s rock atmosphere was less than kind to such endeavors, and when Schon took the speech rhythm section on tour with Paul Rodgers, Hardline folded.
Sunday, 15 June 2008
Tuesday, 3 June 2008
Nadine Coyle dating Josh Hartnett?
Girls Aloud star Nadine Coyle is rumoured to be dating Hollywood actor Josh Hartnett.
The pair have been spotted together in LA several times in the last week, according to the Daily Star.
A source told the newspaper: "The whole of Hollywood was talking about Josh and this pretty Irish girl. Not everyone knows Girls Aloud here so people were trying to work out who this stunning girl was.
"They were spotted at [temporary Oscar venue] Blanco 101 looking very much like a couple and chatting over drinks until the early hours."
Last month Derry-born star Nadine split with 'Desperate Housewives' actor Jesse Metcalfe after an on-off relationship.
She recently dismissed speculation that she was preparing to quit Girls Aloud.
The pair have been spotted together in LA several times in the last week, according to the Daily Star.
A source told the newspaper: "The whole of Hollywood was talking about Josh and this pretty Irish girl. Not everyone knows Girls Aloud here so people were trying to work out who this stunning girl was.
"They were spotted at [temporary Oscar venue] Blanco 101 looking very much like a couple and chatting over drinks until the early hours."
Last month Derry-born star Nadine split with 'Desperate Housewives' actor Jesse Metcalfe after an on-off relationship.
She recently dismissed speculation that she was preparing to quit Girls Aloud.
Wednesday, 28 May 2008
'Idol' Syesha Mercado's ouster leaves two
During Tuesday's performance segment, "American Idol [ tickets ]" judges Simon Cowell and Paula Abdul accurately predicted which contestant was packing up and going home Wednesday (5/14): Syesha Mercado. Now it's down to David Cook versus David Archuleta.This week, the contestants performed three songs: one they chose themselves, one chosen by one of the judges (Cowell, Abdul and Randy Jackson), and one chosen by the show's producers. Mercado selected Peggy Lee's "Fever.""I think you will probably regret that decision tomorrow," Cowell said after Mercado sang the cut. "It was quite a lame cabaret performance."Abdul said Mercado's second performance, "Hit Me Up," from the film "Happy Feet," was not good enough to warrant a spot in the finals.Rounding out Mercado's performance was a rendition of Alicia Keys' "If I Ain't Got You." Jackson, who selected the song for Mercado, summed up her performance by saying that she was peaking. But it wasn't enough.Archuleta kicked off Tuesday's show with a rendition of Billy Joel's "And So It Goes," a song chosen by Abdul. "Paula chose a dope song for you," Jackson said. "The Billy Joel thing works well for you. You are in the zone. You are in it to win it, baby." The judges weren't as complimentary when Archuleta sang Chris Brown's "With You." Cowell compared his performance to a "Chihuahua trying to be a tiger." Jackson wasn't too kind either. "I applaud the fact that you're trying something new and young," Jackson explained. "But I'm not sure that's the right song. Hearing you sing [the phrase] 'my boo'--I couldn't believe it."For his last song, Archuleta performed "Longer" by Dan Fogelberg, a tune that Cowell called "gooey." Jackson said Archuleta could sing the phone book and be successful, and Abdul dubbed his performance "lovely." Cowell chose Roberta Flack's "First Time Ever I Saw Your Face" for Cook, and Jackson said he wished his cohort would have chosen a different song. Cowell, who said he was not biased, called it Cook's best performance to date. Cook laid into Switchfoot's "Dare You to Move," a performance Jackson described as "pitchy." Abdul softened the blow by acknowledging that it was challenging to condense a three-minute song into a one-minute performance. Cowell agreed. The producers chose Aerosmith's "I Don't Want to Miss a Thing" for Cook, who garnered great reviews for his take on the song. Abdul predicted she would see Cook "in the finals."Jackson called it one of the greatest songs of all time and said, "I have to tell you: David Cook wins the night."
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